Intrathecal Mesenchymal Stem Cells for MS Randomized Trial (Tisch MS Center)

I really admire your consistent efforts for giving this valuable knowledge. Keep doing this definitely you will explore the best and something special about this area in future.

Thanks for sharing this data. My mother in law and a family friend began treatment at TISCH over 20 years ago, but have since found local neurologists. NYC is at least an hour and a half train ride for us (on a good transit day). I agree with you on the results. As a spinal tap veteran, I would not be willing to subject myself to 10 taps unless these results were more significant. However, if I had severe disability I'd probably be willing to try anything. Not much to lose in that case.

I've never clicked on a video so fast!! Thank you Dr. Beaber for your openness and consideration to different options ❤

Hey doctor, do you accept pateints? If so, what is your typical wait time? You are by far the most intelligent and knowledgable neurologist ive come accross.

Thank you to one of the GREATEST Neurologist ever!!!

I was incredibly eager to listen to your interpretation of this trials results. I was hoping your analysis would be a little more optimistic based on the results. As a patient with SPMS I feel as though being a part of a trial like this is a win win, with the benefits certainly outweighing the risks.

You couldn't get ME to receive a treatment involving spinal taps to save my LIFE. I refused a urodynamic test on the grounds that "I don't like the protocol on that one". They're lucky they got me onto the Ocravus, and between us - besides, of course, not to minimize, a stable MRI - that's not helping either. 😔

Could you do a video for RRMS people that have failed all the drugs (high JC titer, low 53 bpm heart rate, got uc symptoms from kesimpta, sick from abagio) the only drug left is mavenclad, which scares me. When would something like this or other alternative treatments be available for the rest of us?

I was a patient there for ten years. I was treated very well by the staff and doctors. I was not selected to be a part of the trial (I believe the patients selected were from Dr. Sadiq's patient roster only.. no medicare people $?). Of course, as a patient with progressive disease I would take any opportunity to participate if even there was a possibility for the distant chance at getting any improvement. You’re basically a vegetable with a vocabulary at this point, what have you got to lose? I appreciate they are great efforts, it’s unfortunate. The results are lackluster. I read a recent article about stem cell treatment securing people from HIV. The way healthcare works we are living longer, but are we living better?

Hi from Israel thanks for the update data always waiting to your videos

Your question at the end is always a pertinent one to anyone with PPMS. Would you participate in phase 3 trial? Personally, I would but not a blinded one. One thing neurologists need to do is put themselves in the shoes of the patient, so to speak. Given the narrow number of DMTs available to PPMS patients you very much feel 'stuck' and you're always wondering when you'll end up in a wheelchair. This means our tolerance for 'risk' might be higher than our neurologist's. So, personally, if the side effects are low risk, I'm happy to try, but I don't want the placebo, I always feel like there's a clock ticking, time is of the essence. I often think of the study Dr. Giavonnoni did where subcutaneous cladribine showed a very positive effect in patients with PPMS. I'd try it in a heartbeat, today. But good luck finding a doc who'd let you try off label.

Interesting… #Sharingiscaring I think if I were recently diagnosed with ppms- I’d give it a go. Not at this point in my journey tho

Thanks Dr. Beaber! Interesting video. I really enjoy when you break down these studies. Would I participate in a study of this kind? My initial response was “no way!” - 10 spinal taps? Yikes! But, if I had PPMS I might feel differently.

Thank you for the information doctor! Pathologist Dr. Alan MacDonald discovered novel tape worm larvae in all ten MS brains he examined. The study and pictures of the slides are available online to view. This was not peer reviewed, but it sure would explain perivenular inflammation in the brain (which proceeds lesions in MS), don’t ya think? I believe all your viewers would enjoy a discussion about this topic, maybe even an interview with Dr. MacDonald? Thanks!!

What do you think about the insertion of Mesenchimal stem cells via i/v? The collection of those cells from the body’s fat cells? I am thinking about this kind of procedure in a clinic in Germany. I was diagnosed 10 years ago and have an edss of 6,5-7 Thank you!

Dr Beaber - you are the best! We are grateful for your analysis. I would have to know about the stem cells themselves. Are the embryonic fetal tissue cells? I would also have to be pretty desperate to receive that many spinal taps? I steered clear of this even at diagnosis. Thank you again & happy summer

Thank you for giving this an honest review. There are so many with PPMS and Ocrevus just isn't cutting it for them- what other choice do they have? I'm a FB moderator and finally a good video to share with them ;-)

If there was massive improvements the study might be worth something, but if that were the case they wouldn't need s lot of people in the study and it wouldn't have to be blinded since it would be so obvious. Did these studies equalize vitamin d at a nice level in the upper half of the range and vitamin k2 blood levels along with whatever else is known to help stem cells proliferate and survive? Or did they, (which I would suspect is most likely) ignore the diet and everything else that would be conducive to stem cell longevity? Hyperbaric oxygen stimulates stem cells, why wouldn't they add that to what they're doing to give them the best chance of stem cell survival? Did they include anyone on warfarin? I'm going to take a wild guess here, the subjects in the study had diets that were not conducive to their own stern cells working properly in the first place. Is that the way it was?

I agree with you. I wouldn’t enter a phase 3 trial, no way.

How disappointing. I wouldn't undergo all this for slight improvement. But i also don't have ppms. 😢