Multiple Sclerosis Pathology

Thank you, Dr. Beaber, for raising awareness about such a sensitive topic. I was recently diagnosed, and my neurologist recommended ofatumumab injections for me. Just to give you some background, I'm 27 years old from Italy and had no symptoms until last December when I experienced paresthesia on the left side of my face. About three weeks later, weakness appeared in my right hand and lower leg. I was prescribed high doses of steroids for five days, which quickly alleviated the weakness. In February, I was hospitalized briefly to expedite the diagnostic process and undergo necessary tests. While I have multiple lesions, including some in the cervical spine, they are not particularly large, and some showed gadolinium enhancement. Currently, I have no active lesions, likely due to the steroids. I still have slight paresthesia on the right side of my face, but it's minimal. I'm feeling very optimistic and hopeful that Kesimpta won't cause any major side effects. Thanks again, Dr. Beaber, for your informative videos; they've helped me overcome my fear of this illness.

Wow awesome information! I wish I had you to go with me for my disability hearing tomorrow 😊..... Thank you

Going to school with Dr. Beaber on Wednesdays! Thanks so much for the lesson. I love gaining a better understanding what is happening. Because there are 4 different patterns of lesions, is it possible that there are different diseases? Edit: Yes! I would be willing to donate my brain. I will discuss it with my neurologist at my next appointment!

Grand rising Dr. This is so amazing and helpful. I received this diagnosis back in 2011 and honestly nobody explained anything to me other than saying it's a lifelong disease that will eventually get worse and kill me. I'm literally just now getting the actual documentation of my MRI and everything else. I was never given anything, the only thing I was given was a suggestion for me to enter a trial that the neurologist was involved with. And so I never even took any medicine so I surely wasn't going to do that. So fast forward a decade thank God I didn't take the medicine but anywho I fell leaving the pool and it brought everything to the forefront so I'm going to quit talking my message in and now and just listen to the rest of what you got to say but brother you are so appreciated! I hope you have a magnificent day

Just recently diagnosed with RRMS and I've just begun ocrevus infusions! I really appreciate a doctor taking their time to explain things about MS, definitely subscribing 🙏

I would never let my CSF be monkeyed with again, my Spinal tap was very uncomfortable. I am 53 years old in May a woman I’ve had multiple sclerosis for 35 years. I’m still able to drive and walk although I did just have a really bad relapse in November but I’m coming back from it almost 100% now. So whatever you do, don’t give up.

Thanks for your videos.l I wish you were in NY!

Thank you very much for making this video, or any video for that matter as I usually feel more informed and "in the loop" if that makes sense. My MS Neuro team is amazing and they take and make time to properly listen to me and treat me. However, your videos help me to get another perspective and food for thought. In this case, donating my brain. I'm certainly open to it if this is permitted in my faith which I will check.

Thank you. Have filled out the paperwork for letting science have at my brain when I am gone. TBH it's a less creepy thought for me than the usual exit routes!

Thank you Dr., I love your videos, I always learn something.

Awesome video!

I don't know if you saw it but I responded in a tweet on X with a clinical study on a emerging stem cell treatment (phase1). If you did see it I would love for you to do an overview on it. It seemed like a prety extreme intervention that I had many questions about, such as is the cranial hole is permament or do they seal it after the injection.

I would donate my brain. I wont need it anymore, so why waste a perfectly damaged brain?! 😅 I dont even know where to start that whole process. I loved this video. Sooo fascinating to me. Those slides are incredible- seeing the cells eating the myelin. Thank you! Have a good day

This was a VERY interesting video. I remember the brain bank for MS donations- of brains 🧠- it’s nice to see what they’ve come up with all the research they’ve done. I found it interesting that even the “ normal “ brain 🧠 tissue had a few cells as well. ❤ #Sharingiscaring

Thanks Doc. I am in the KP system/SD chapter w/ Dr. Matich so only 2 hrs away. Very heavy burden of Lesions but I guess I am operating fairly well at this time.

Fascinating video Dr. BB. Thank you. I am a medically retired engineer; cheers MS. So a lot of this extremely biological content isn't my bag. But! It shows the extent of #MS research and a lot of the possible 'hows'; engineer 😅. Brilliant. I'm 46, with RMS since maybe '97, now with Ocrevus

I think a study of individuals who have had re-mylenation naturally occur would be useful. Especially their genetics, biology etc. if any die, their brains biopsy would be useful too. Could help us learn what exactly is different about them. I have seen several ocrevus users whose lesions went away. I haven’t had that even though I have had MS since I was 13 and would probably have a higher chance of repair due to my age.

Hi Dr. Brandon, I learn a lot from your videos. I wish if I could book an appointment with you. In Sweden we should choose our medication ourselves and i am lost! Regards.

Would you do a video on neural reserve/neural redundancy and how best to implement it, please?

What do very late stages of Secondary Progressive MS look like in a female 55 yo? How do you know if the brain is deteriorating to a point where additional treatment or exam is needed?