What Symptom Does Each Multiple Sclerosis MRI Lesion Cause? Neurologist Explains

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Published 2023-08-30
0:19 Optic nerve
1:30 spinal cord
7:03 Corpus Callosum
9:03 Splenium of the corpus callosum
10:36 Periventricular
12:58 occipital
14:13 Frontal
15:13 Posterior pons
16:33 VI nucleus
17:06 Broca’s area
18:13 Cerebellum
19:00 Middle cerebellar peduncle
19:15 Area Postrema

My patients often ask me what symptoms would be expected based on an MS MRI lesion in a particular location. This reviews MRI scans showing common MS lesions and their associated symptoms. Keep in mind that actual symptoms vary considerably based on the amount of injury to the underlying nerve fibers associated with that lesion.
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Dr. Brandon Beaber is a board-certified neurologist with subspecialty training in multiple sclerosis and other immunological diseases of the nervous system. He is a partner in the Southern California Permanente Medical Group and practices in Downey, California (South Los Angeles). He has several publications on MS epidemiology and has participated in clinical trials for MS therapeutics. You can follow him on twitter @Brandon_Beaber where he regularly posts about MS news and research.

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he video material by Dr. Brandon Beaber is general educational material on health conditions and is not intended to be used by viewers to diagnose or treat any individual's medical condition. Specifically, this material is not a substitute for individualized diagnostic and treatment advice by a qualified medical/health practitioner, licensed in your jurisdiction, who has access to the relevant information available from diagnostic testing, medical interviews, and a physical examination. To the extent that Dr. Beaber endorses any lifestyle change, behavioral intervention, or supplements, the viewer should consult with a qualified healthcare professional to determine the safety and efficacy of the intervention in light of their individualized information.

All Comments (21)
  • @BioMedUSA
    Thousands of hours of your efforts studying / practicing condensed into an incredibly lucid presentation. What a gift you gave!
  • @jomamapalmer9223
    Absolutely phenomenal!!! Dr. Beaber, you teach so clearly and easy to understand. Thank you for your clarity and taking the time to make these videos to help teach us about this MonSter! You are so appreciated!
  • I can't thank you enough for taking the time to break down the potential functional impact of lesions in various locations of the brain. I have over 30 lesions with 20 of them "black holes". I am aware that all cases are different and no one can conclusively predict the impact a specific lesion will have. However, your explanations helped me gain insights that truly offer me comfort (regardless of outcomes). Thank you. Lezlie
  • @jkislearning6560
    I would like you to do a talk specifically on which brain and/or spinal cord lesions impact bladder and bowel function.
  • Thrilled to say I have lesions in almost all of these areas 😆 I had one very hard relapse involving so many of the symptoms you mentioned, the worst of them being caused by lesions in the pons and cerebellum. It's terrifying to have double vision, inability to move your eyes to the side, and on top of that have debilitating vertigo and loss of balance. Among other things. It's like being barely conscious
  • @lauracarlson9260
    I really wish our neuros would go over this with us both when we have symptoms that point towards lesions and when there are lesions (especially new ones) on our MRIs. I think it is because they don't want to ask "leading questions" perhaps. But I think knowing really helps. Also when lesions are in certain areas you'd think that you'd be recommended to PT to help with rebuilding neuroplasticity
  • Gonna have to watch this a few more times to learn as much as I can. After 12 years of neurologist visits I finally briefly was able to view my wife’s MRI after pleading repeatedly with her doc. Was just a quick view, the doctor pointed out some grey matter shrinkage from a sagittal view and lesions that looked like white mist in the center of the brain. The doctor didn’t say much more then “this imaging is typical of MS”. My wife is almost bed ridden with severe hand contractures and right side weakness. Two initial questions I’m having are: how much can nueroplasticity and creating new Nuero pathways can overcome the damage from lesions, and also I wonder what percentage of the general population has brain lesions? My wife has been diagnosed for over 25 yrs and I fear that she has permanent neurological damage (in this life, at least). I will watch this video again. Very informative! Thanks Dr. Beaber!
  • @klburke
    Thank you for this video! It was very helpful and educational! My neurologist never shows me my MRI's, because apparently there is never enough time in our hurried appointment🙄 I do however have the written reports (that my GP emails to me because my neuro won't show me that either), so this video is very useful to me. You made me laugh at around the 1:50 mark when you talked about the way of keeping the riff raff out of neurology. I love your subtle humour! Have a great day
  • @tawny-fw7cc9iy6k
    Thank you my lower leg and arm on the right side is affected with weakness and feel cold most of the time. First symptom was Optic neuritis in my right eye 10 years previous. This explains a lot more thank you
  • @EvenSoItIsWell
    Very cool! Geeking out with Dr. Beaber this morning. Thanks!
  • @MaiC-
    Thanks doc, appreciate this informative video, I've learned more today than I have in 3 years and can make sense of what is happening to me. Thank you
  • @hw7029
    It seems like a lot has been learnt about MS in the past decade. I was diagnosed in 2009 (though had v.obvious Neuro symptoms for several years preceding). At the time of diagnosis the thinking was there was no proven correlation between lesion number/location and symptoms. I had a really sizeable spinal lesion, but last time I was scanned remyelination had repaired much of that lesion
  • You have helped so much in my MS journey. It totally fits. I have periventricular lesions in my left side of the brain and it matches the numbness and tingling in my right leg!! Things make sense now.
  • @feystrange
    really clean concise explanations here, I so appreciate this! I have a litany of neurological issues and learning more specifics is giving me the courage to seek help. the experience of neuro symptoms is soo bizarre— getting information feels grounding, like making sense of sensations that defy logic!
  • @msguidedbits9511
    Thank you, I find this so interesting. I had a painful and interesting MS reaction this week. I smashed my left thumb, when I forgot to close the door by the handle, and simply pushed it shut, catching my partially numb thumb in the door. I didn’t realize the severity of the injury at first, as I wasn’t feeling the extent of the pain. Went to urgent care… after coming back I was waiting for my kids returning from school, and the pain was increasing in my thumb. I realized my other fingers, in both hands had been temporarily restored to normal feeling with no pins and needles. I had only taken Tylenol at that point for pain. My fingers returned to my numbish, tingling feelings, in an hour or so. Though the injury was incredibly painful, feeling the normal feeling in the rest of my fingers, well I didn’t think I would ever feel that normal feeling again. (Please don’t try this at home. Nail is badly damaged and tip of thumb is fractured.) 🙃
  • @mollywest3087
    Thanks so much!! I’ve always wondered about this
  • @francheska1431
    My biggest attack was a 3cm lesion that initially looked like a tumor to drs, I couldnt talk properly suttering and talking gibberish and I couldn't write properly either for a while, frustrating kinda like being 2 again
  • Thanks for breaking this down. Brain lessions sound scary. You describe them as causing symptoms. I get symptoms all the time! I just deal with them as they come up, and swallow Omega, exercise and play word games to avoid further ones. So until my symptoms haven't included dementia to the point that I forget who you or my loved ones are, I guess we'll manage! Shana Tova U'Metuka from Jerusalem! ⚖️🖋 📙 🍯 🍎