Ocrevus vs. Kesimpta for Multiple Sclerosis. Comparison Between the Drugs, Efficacy, Side Effects

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Published 2020-10-28
Ocrevus (ocrelizumab) and Kesimpta (ofatumumab) are two drugs for multiple sclerosis which both work on b-cells. In this video, I explain differences between the two drugs and results from clinical trials. Which drug has fewer drug-reactions? Which has a lower rate of serious infections? Is Kesimpta more optimally dosed?

Sources:

Subgroup analysis of OPERA trials: www.ncbi.nlm.nih.gov/pmc/articles/PMC6469695/

OPERA trials: www.nejm.org/doi/full/10.1056/NEJMoa1601277

NEJM article summarizing the ASCLEPIOS trials: www.nejm.org/doi/10.1056/NEJMoa1917246



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Dr. Brandon Beaber is a board-certified neurologist with subspecialty training in multiple sclerosis and other immunological diseases of the nervous system. He is a partner in the Southern California Permanente Medical Group and practices in Downey, California (South Los Angeles). He has several publications on MS epidemiology and has participated in clinical trials for MS therapeutics. You can follow him on twitter @Brandon_Beaber where he regularly posts about MS news and research.

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The video material by Dr. Brandon Beaber is general educational material on health conditions and is not intended to be used by viewers to diagnose or treat any individual's medical condition. Specifically, this material is not a substitute for individualized diagnostic and treatment advice by a qualified medical/health practitioner, licensed in your jurisdiction, who has access to the relevant information available from diagnostic testing, medical interviews, and a physical examination. To the extent that Dr. Beaber endorses any lifestyle change, behavioral intervention, or supplements, the viewer should consult with a qualified healthcare professional to determine the safety and efficacy of the intervention in light of their individualized information.

All Comments (21)
  • @user-zu7hw4kz3g
    I am sending a hug to anyone who is scared now. I wish I could just be there with you, sitting in silence.
  • I'm fairly new to Kesimpta. I started it in January 2023 and I like it. No allergies, no adverse reactions, no infections, nothing negative about it for me. No relapses, brain fog, no seeing little black spots. Nothing, I am grateful 😊
  • Switched from Ocrevus to Kesimpta and have experienced monthly joint and muscle pain along with a facial breakouts. Switching back to Ocrevus where I had nothing but improved quality of life for 2 years. The switch was made due to concerns over the breast cancer risk. This video helped me to understand those concerns a bit better. Thank you.
  • @epjohnston
    Just found this video. Great explanation of the differences and similarities. I was on Ocrevus for a year and a half and then switched to Kesimpta. I've been on Kesimpta for a year now. From a patient experience, I find Kesimpta so much better. The Ocrevus infusions felt like a big deal on infusion day and for the next few days after. Not to mention the steroid and antihistamine protocol before receiving Ocrevus. With Kesimpta, it's just a quick shot and I go on about my business. I rarely ever feel any difference in my body after the shot.
  • @mg.1680
    Very good summary! Thanks for this video.👍
  • @aditya50499
    Thank you Dr. Beaber for doing such informative videos for us.
  • @christinek2235
    Really appreciate your videos! Great information. Thank you!
  • @commonsense99
    Love this Dr. Beaber! Thanks so much. I was dx with MS in November 2000. Lucky to have not had very much progression of the disease. I kept quiet about having MS (Multiple sclerosis) for over two decades. I lived and battled my MS in the shadows. Why? One of many examples of living with a chronic disease when people don't know you have it, I had an employer take myself and another lady into a backroom and tell us “Don't hire anybody with a chronic disease like MS our insurance rates are going through the roof!” He didn't know I had MS. Another employer told me behind closed doors, “I wished more of the employees kept in shape like you, we have a couple of fatties that are diabetics, and they are driving our healthcare costs up.” Age and health status discrimination is alive and well because our healthcare costs have skyrocketed. I have friends that are self-employed married couples, 60 yrs. old, that makes too much for the subsidy and they can’t afford healthcare. What a crime! And…. I've had doctors that didn't know I had MS say some mortifying stuff in front of me that they didn't know what they were saying was unethical and scary! But I've also had one of the top oncologist doctors in Idaho that have told my story above and they actually started crying and said that the United States medical system is corrupt, his exact word were, “It’s f#cking corrupt!” My third book will be about what I have seen and heard living with a chronic disease on others not knowing it. What I saw and heard will terrify you.
  • Thank you so much for all this information, my husband is treated with Ocrevus (this is the way it is written here in France) and was asking himself if he would not change for Kesimpta (this is also the way we write it in France) and your help is absolutly great! Thank you 😃
  • @cesarramos7488
    Thank you for the information. My wife will start Kesimpta treatment soon. We are nervous and your i for Action is very helpful. Thank you 🙏🏼
  • @diamondbrown79
    I'm so glad I found your channel! My mom was diagnosed with MS after YEARS of being treated for fibromyalgia 🥴. I haven't understood her condition and have felt a little unsupportive for some time. I'm hoping to learn more about MS to support her more. I appreciate the in-depth explanation of these drugs too. Idk if she takes anything like this so I'm happy to have something to share 🤗. Thank you
  • @cinlou5804
    Helpful, as I’m trying to decide between the two right now.
  • Thank you as always for the time you put into these videos! Information always brings a bit of calm to all the craziness. My neurologist is recommending Kesimpta as my first treatment, so trying to find out as much as I can!
  • Very happy and appreciative of the video. I’m currently on ocrevus and contemplated changing to kesimpta. I wondered how the two B cell depletions would compare. Very informative. Thank you ! I think for now I’m going to keep the course only because I seem to be doing well. And I don’t know how I feel about injecting myself. Haha. I’m a nurse and find it odd that I’m fearful of injecting myself. 😊. Have a nice week
  • @rc4156
    I've had 2 Ocrevus doses so far, about to have my third, and I've noticed each time that I've had what feels very much like a relapse and persistent worsening of symptoms sound the 4-5 month mark. When I read that Kesimpta is a monthly injection my first thought was 'does that mean no crap gap?' because of the more consistent dosing. I am very keen to speak to my consultant about this, as I'm concerned that more permanent damage is occurring every time I am coming up to my next infusion.