Bruton's Tyrosine Kinase Inhibitors for Multiple Sclerosis Explained by Neurologist

Very nice video. We're actively involved in several of these trials at present.

I was part of the evolutionRMS2 study. Evobrutinib vs Aubagio. The center that I was at was absolutely horrible about listening to side effects, and I left for my own safety. I hope others have a better experience in trials. I absolutely recommend doing things for science, but remember that you're your best advocate!

I am involved in Gemini I and II. Glad to hear about this topic, thanks for the video. I have been in the trial for 1,5 years, haven't had any relapses since then and since my diagnosis. I was diagnosed two years ago, in my country you can get medicine if you have at least 2 flair ups, so I was happy I could begin taking trial medicine.

Thank you Dr Beaber for this high quality information! It's wonderful to have someone who updates us on new information. Also wonderful to go to our Dr. appointments so well informed.

Great content as always Dr. Beaber. If my MS transitions to the progressive form with no active relapse/lesions I would like to try BTK inhibitors. Hopefully they will show better efficacy against progression than other DMTs✌🏼

Thanks Dr Beaber, one of the best video reviews of BTKi I've seen so far.

Science will save us. Thanks Dr. Beaber. B cell depletors made a great success. As I see Bruton's Tyrosine Kinase Inhibitors have the potential for another breakthrough. Can't wait for more phase 3 trials.

Currently part of the fenebrutinib study! This video really helped me understand it even better ❤

I have been fortunate to study with in my field (music) with some world class innovators. They not only passed on knowledge and skills, but also more inspired me and in a sense made me smarter or more spongelike/receptive and thirstier for knowledge. The realities of the universe are limitless and the status quo and existing arsenal at any time must be constantly be re-born and re-discovered. If a music creator is in the zone ANY moment offers new possibilities the well never runs dry. It should be no different in other fields. Thank you good Dr. Brandon Beaber for delivering this and other videos which explain, the gist , the details, the caveats & confounders, help us (MSers) be inspired more spongelike students. The being hopeful part is ultimately in our personal domain and so, your lack of affectation (though u r passionate and fearless) is appropriate I think for many of us fighting MS whoin the end need to have a positive psychological visualization in bettering our health through the intangible faith like x-factor (whether we are Darwinians, or scripturists or whatever stripe). My HSCT at Ruiz happens this Sept 2023 in Puebla. I didn't have slowed progression on B cell depletion. I'm 59 with PPMS, and this HSCT is not a slam-dunk but I've heard from many (even those with PPMS some even older than me) who have had their progression halted. I'm still with out cane and performing music live and in the studios but progression is not halting, so endless thanks for this and all your work.

Thank you so much sir !! You are a wonderful person bless your soul, may your days be always prosperous and healthy

Thanks for the video! Has me excited! I have also heard about imu-838 being in late stage trials and showing protection against smoldering. Would love a video about it! Thanks again!

Doctor Beaber you are true professional. Thank you for all this info.

Hey Doc! Thank you for the great content as always! I was diagnosed with probable MS after my first attack of ascending numbness up to right around my chest + positive Lhermitte’s. MRI showed 12-14 small lesions in the brain ( some enhancing ) and one lesion in the cervical spine. After 1 week of Solumedrol, my CSF came back positive for Lyme (elisa) and they started me on Ceftriaxone for 3 weeks. Everything resolved within 2 months except a bit of Lhermitte’s and internal tremors after running/walking. 3 years fastforward, I had another attack - exact same symptoms but this time I took no medication and it resolved within 3 months . (No change in my MRI of head and cervix) My neuro prescribed hypothalamus phospholipids alongside high dose B1+6+12 shots for 10 days due to my reluctance to start on DMDs. I understand you cannot provide medical advice but any comments/thoughts would be highly appreciated! I am 26 male and very worried for my health! Please, let me know if you provide paid online consultations! I would so love for you to be my neuro! I live in Azerbaijan and we have no MS specialists here.

Thanks for the great explanation! I’m hoping for the best for BTK inhibitors. I’m one of those older people who needs something besides an immune suppressor DMT.

Excellent video thank you Dr Beaber!

Thanks so much Dr. Beaber. It is so encouraging that there may be another option soon for people with MS. Could you do a video explaining the difference between smoldering MS (PIRA) and SPMS & PPMS?

Any new updates on the stemcell transplant trials? I applied for the one in San Diego and am waiting for the next step after Dr Burt requested my actual MRIs to review. My ms neuro said in the most recent journal that the results are coming in to be not much better than the big gun DMTs what are your thoughts? Love these kind of videos! Ive been rooting for DKT. The Primary progressive warriors really NEED help!! THANK YOU!!

Good and informative video as always! 🙏 I have been on a clinical trial Evobrutinib against Tecfidera for nearly 2 years 2017-2019, no major side effects, maybe some bloating if I recall correctly, but I got one nasty relapse in that period. The good thing was that on MRI one of my lesions had disappeared.

great content!

Thank you for this information! I wasn't able to join a BTKi trial because my lymphocyte count was just under the requirement after 9 years on Gilenya. I've had MS for 24 years and I'm looking forward to BTKi or other therapies that will target smoldering MS. I'd love to learn more about how infections may activate MS and induce activity. Last year after a mild case of COVID-19, my MRI showed an enhancing lesion for the first time in more than 12 years, though I wasn't having specific symptoms of a relapse.