The Coagulation Cascade - Intrinsic & Extrinsic- Most COMPREHENSIVE Explanation - Hematology
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Published 2019-03-14
The coagulation cascade is aka secondary hemostasis...Its main job is to convert fibrinogen into a strong fibrin meshwork that will trap the red blood cells and stop the bleeding.
These coagulation factors are beta globulins (vs immunoglobulins "aka antibodies" which are gamma globulins).
This secondary hemostasis comes after primary hemostasis (the temporary platelet plug)
Primary hemostasis is balanced on the dynamic harmonious antagonism between the smooth endothelium (that prefers laminar blood flow) and thrombocytes (which favor clotting and thrombosis).
Platelets are called thrombocytes "cells of thrombus".
The smooth endothelium is squamous epithelium that lines the blood and lymphatic vessels from the inside.
When platelets roll over the smooth endothelium, nothing happens.
But, once there is an injured endothelium, platelets adhere, activate and aggregate to form a temporary platelet plug (primary hemostasis).
Then, the coagulation factors are stimulated "thanks to subendothelial collagen, tissue thromboplastin and platelet factor 3), coagulation cascade ensues until fibrinogen is converted into fibrin fibers trapping the RBCs and forming a stronger thrombus (secondary hemostasis).
After that, fibrinolysis occur (thanks to tissue plasminogen activator or tPA) to destroy the clot and restore function and flow.
Hemostasis is defined as “cessation of blood bleeding”.
There are 2 types of hemostasis:
1. Primary hemostasis: formation of weak, temporary platelet plug (by platelets).
2. Secondary hemostasis: formation of stronger fibrin meshwork (by coagulation factors).
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All Comments (21)
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Even when you explain it “like my professor” u explain it better looool
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Trust me when I get into med school and finish my MD my salary is going for your patreaon account 🔥🔥🔥
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Someone pls give this man an oscar for best male actor for his 3:31 performance because it is exactly like my professors
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I've had so many "OHHHH so that's how it works" moments watching your videos it's crazy! Thank you for explaining the material so thoroughly yet easy to follow! Love your channel!
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Another mnemonic for PT & PTT for expression of extrensic Abd Intrinsic pathway is that PT= Play Tennis >>outside door >>extrinsic pathway PTT=Play Table Tennis >>inside >>Intrinsic pathway 🎾🎾🎾 Foe answer I think the entire of tube is like blood vessel wall
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Med student here. Your way of sharing knowledge is the best for me! You must be a great doctor and teacher. Please upload more videos, they're literally saving me..😭
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I never knew I could laugh while studying coagulation cascade , cheers to you sir !
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"Let me explain it like your professor " me : *having intense flashbacks"
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" Let me explain like your professor" --> # Sleeping mode on
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You definitely deserve a millions subscribers. I’ve tried to study the coag cascade so many times and never really could until I watched your videos. Thank you thank you thank you!!!
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Always thought of the cascade as something I could never learn and only cram it. You've solved my problem. Thank you.
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ive been trying to learn this but i really couldnt to the point that i lost motivation and stopped studying for weeks but you really made it look very easy and simple you are a life saver thank you !
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Brilliant! Blood clots when it touches the glass tube and factor 12 is activated
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great explanation. I could never remember the coag pathway and after spending 20 min watching this video I feel like I'm now an expert. thank you!
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I think I will finally remember the coagulation pathway. Thank you so much. Every time this topic comes up I feel like I have to relearn it because it never sticks. You are a savior!!!
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Really helpful! thanks Answer: the intrinsic pathway can be activated when the blood is in contact with a surface different from the vascular endothelium. If an injury occurs, the blood will be in contact with the SEC, but if it is placed in a test tube ( made of glass), the cascade can also be activated.
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I’ve been a Medtech for 10 years and I think this is the first time I remember every step of this damn cascade great job 👏🏽. Ive always heard it explained like your example of a professor. I’m pretty sure “go to hell”was said also.
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You're awesome! When you said, pause the video and try to repeat it yourself, I was surprised that I could do it without stoping at any point to memorize what you were saying. Thank you so much!
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"Use your prefrontal cortex for heaven seck" I'm dying laughing
