Manolis Kellis: Biology of Disease | Lex Fridman Podcast #133

Here are the timestamps. Please check out our sponsors to support this podcast. 0:00 - Introduction & sponsor mentions: - SEMrush: www.semrush.com/partner/lex/ to get a free month of Guru - Pessimists Archive: pessimists.co/ - Eight Sleep: www.eightsleep.com/lex and use code LEX to get $200 off - BetterHelp: betterhelp.com/lex to get 10% off 2:49 - Molecular basis for human disease 26:48 - Deadliest diseases 32:31 - Genetic component of diseases 41:22 - Genetic understanding of disease 57:09 - Unified theory of human disease 1:03:10 - Genome circuitry 1:28:13 - CRISPR 1:39:50 - Mitochondria 1:47:54 - Future of biology research 2:17:30 - The genetic circuitry of disease

Manolis is the most concise explainer of abstract and complicated topics I've ever heard.

Bring him every time you want. Manollis is simply amazingly inspiring

"Don't get me started" - Manolis Kellis catchphrase

Lex please round 4 5 6 7... i can listen to this guy 4 ever

Me:*Sees 'Manolis Kellis: Round 3' Also me: "Don't get me started!"

The first Monday of each month should be Manolis Monday on the Lex Friedman Podcast ❤

Started my PhD in Molecular Biology this month. I needed this. Thank you, Lex

One of my favorite parts - Manolis: "So, you have a bowl of noodles" Lex: "Go on..." Manolis is really such a great communicator. I deeply envy his students! On another note, great to see you outside of your comfort zone, Lex! That's where all the growth is.

Don't forget... Lex is vital in our live for Manollis... Lex is half of this conversation. So Lex, we want more of Manollis on Your podcast. Not just random talks from him. You are complicit with our enjoyment here, so thank you too! Not speaking for anyone else, but my guess is more commenting here feel the same. You, like Joe Rogan, have a gift for bringing out the best in people.

What I love about Lex's podcasts is that such smart conversations are made for the audience. Manolis doesn't explain stuff to Lex, because many things he already knows, and they both know it. He explains to the audience. Lex doesn't ask some questions for him to understand, he may already know it, from own studies or from conversations outside the podcast. Lex wants the audience to know the answers. And for myself Lex is asking right questions at a right time. Just really great podcast.

A podcast that you can't listen to in the background is the best kind of podcast. It's so rich in information. Love it!

gosh, I would love to hear a one hour in depth conversation about mitochondria!!

the way he breaks apart extremely complex concepts into simplistic steps is amazing.

This podcast could turn into the Lex and Manolis show and I'd be perfectly happy with that

I rarely comment on YouTube videos, but Manolis is such an inspiring guest. Keep the fun conversations coming.

Manolis' Youtube channel has the complete video of two of his computational biology courses . What a gift! He has a great way to explain super complex ideas in simple terms. Bravo!

Manolis is a fascinating personality. My favorite guest on your podcast

Hell yea! The last 2 times he's been on has been amazing

I feel so amazed, enlightened and enjoyable every time I listen to Manolis' wisdom! Thank you!