Is MS Actually Autoimmune?

Published 2022-11-02
0:28 Immunosuppressants
1:54 bruton’s agammaglobulinemia
3:30 Genetics
4:04 Demographics
4:34 Pregnancy
5:09 Immunostimulants
5:36 Checkpoint inhibitors
6:29 Animal Studies
7:06 Biomarkers
7:46 Glatiramer acetate
8:53 Caveat

Selected Sources:

1) prevalence bruton's agammaglobulinemia: emedicine.medscape.com/article/885625-overview#:~:….
2) Rate of Pregnancy-Related Relapse in Multiple Sclerosis: www.nejm.org/doi/full/10.1056/nejm199807303390501
3) The Role of Granulocyte-Macrophage Colony-Stimulating Factor in Murine Models of Multiple Sclerosis: www.ncbi.nlm.nih.gov/pmc/articles/PMC7140439/ Severe exacerbation of 4) relapsing-remitting multiple sclerosis after G-CSF therapy: www.ncbi.nlm.nih.gov/pmc/articles/PMC4794809/
5) Multiple sclerosis flares associated with recombinant granulocyte colony-stimulating factor: www.researchgate.net/publication/12467935_Multiple…
6)
Treatment of multiple sclerosis with gamma interferon: exacerbations associated with activation of the immune system: pubmed.ncbi.nlm.nih.gov/3110648/
7) Treatment of multiple sclerosis with gamma interferon: exacerbations associated with activation of the immune system: pubmed.ncbi.nlm.nih.gov/3110648/
8) Long-term Clinical Outcomes of Hematopoietic Stem Cell Transplantation in Multiple Sclerosis: n.neurology.org/content/96/8/e1215


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Dr. Brandon Beaber is a board-certified neurologist with subspecialty training in multiple sclerosis and other immunological diseases of the nervous system. He is a partner in the Southern California Permanente Medical Group and practices in Downey, California (South Los Angeles). He has several publications on MS epidemiology and has participated in clinical trials for MS therapeutics. You can follow him on twitter @Brandon_Beaber where he regularly posts about MS news and research.

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he video material by Dr. Brandon Beaber is general educational material on health conditions and is not intended to be used by viewers to diagnose or treat any individual's medical condition. Specifically, this material is not a substitute for individualized diagnostic and treatment advice by a qualified medical/health practitioner, licensed in your jurisdiction, who has access to the relevant information available from diagnostic testing, medical interviews, and a physical examination. To the extent that Dr. Beaber endorses any lifestyle change, behavioral intervention, or supplements, the viewer should consult with a qualified healthcare professional to determine the safety and efficacy of the intervention in light of their individualized information.

All Comments (21)
  • @tomgarbett77
    I completely agree with your last point and that it is in fact due to a cascade of events in concert that result in MS. I believe this is why some people are able to treat the disease naturally by taking out one of those factors, whether it be by making dietary changes, fixing leaky gut, high vitamin D supplementation etc.
  • Great video, thank you! As a person with MS with a masters in public health, I really really appreciate these deep dives of yours into the science and your amazing skill at explaining how scientific studies actually work and what they can/cannot prove
  • @annaconsta
    MS is definitely an autoimmune disease. But I am starting to believe it also has a spiritual side to it. I was self destructive for a great part of my life: self harm and other things. And it's like my immune system reflects my behavior from youth. I didn't like life very much, and it's like the immune system followed that. Maybe our cells are a reflection of our thoughts and we should be gentler with ourselves.
  • I have rrms for 23 years. Im 44 years old. Im on tecfidera now
  • Thanks Dr. Beaber. As always, a very informative video! I would love to see a video on exercise (or PT) and it’s effects on plasticity. Can it help regain function? Thanks!
  • @hw7029
    The immune system is behaving normally in the presence of particular infection/s. Just because your own cells may become collateral damage in the fight against infection doesn't mean the immune system is "deranged"
  • @sandra85
    I believe that without me having severe case of infectious mono when I was 17 I wouldn’t have MS. The best I’ve ever felt since then was when I was pregnant at 25. I felt great during my pregnancy. It would be over 30 long years before I found out what was wrong with me.
  • There's no doubt in my mind that the immune system is involved in MS. Especially, with the meds that eliminate b cells seem to be some of the best treatments for preventing further damage in the CNS. (At least in my case) I have read that perhaps viruses can be one of the triggers that can contribute to the cascade of starting MS. I had a very interesting experience this summer with having covid and taking Paxlovid. It not only helped my covid recovery, but it improved all of my MS symptoms. I was blown away at how well it worked at increasing my walking ability, decreasing brain fog, and greatly decreasing my fatigue. I know this is unusual, but I call covid a blessing in disguise for me. And, it wasn't a temporary effect just during the medication course. Has there been research into antivirals helping MS symptoms?
  • @dominicp134
    for me MS broke out when i lived poorly, slept unreliably and disturbed in sleep, high in sugar and ate poorly, big stress and misantropy, 0 Omega 3 at this time
  • Thank you for this excellent video! Funny, when I was first diagnosed, I blamed my MS on my traumatic childhood and germ exposure due to the disgustingly dirty environment I spent my early childhood in. Perhaps I was wrong and those germs had been one plus for me in that regard. But I did have a bad case of mono in my late teens and following a second pregnancy in my early 20s, that's when I began experiencing what I later realized were my first MS symptoms. So I'm all in on the EBV connection. I love it when you do these kinds of videos!
  • For sure MS is an autoimmune disease! In my personal opinion, the point in MS pathogenesis is to understand the "necessary factor". It looks like EBV could be the only factor shared by all MS patients. In my opinion the effect of Alemtuzumab can explain very good that an external factor is acquired by periferic immune system. MS and EBV could be like Rheumatic fever and Strep. I hope i explained myself correctly, i would love to get your opinion about this!
  • Interesting video. Is it possible that the immune system is not confused at all but rather seeking out EBV, for example, infected tissues in the CNS and trying to clear them? Seems like MS is an autoimmune condition but maybe it is not a mistake and we are not detecting the infection in the tissues attacked…yet? We test for what we know to test for. Interested in your thoughts. Could the high potency treatments also be coincidentally effectively treating the un-identified infection?
  • Hilarious $10 word of the day: Bruton's agammaglobulinemia. Or crudely hyphented for the medical pedestrian like myself: agamma-globulin-emia. Dr. Beaber your video's not only inform our options but profide an optimistic courage, curious wonderment, and let's face it, well needed levity which every person needs (all folks MS or non)
  • @MadMax2022
    Dr B ,this is a fascinating episode of your show ! Great information thanks for this and all you do .
  • Jay the Florida pool pump motor repair guy. When Service Calls Longwood approved ! that was good info 2 know /see👨‍🔧THANK YOU ! Dr. Brandon Beaber 🧑‍🔧🫂👨‍🔬👨‍⚕🧠🧠🧠
  • This is so interesting Doc- as a MS’r in the medical field- this allows me to geek out- ty for explaining all this and using comparisons with other diseases and studies. # Sharingiscaring
  • @emilyanne4008
    Could you do a video on the clinical trial for tolebrutinib? I have an option to join this clinical trial and am trying to weigh options