40Hz Light and Sound (Peak 10kHz) Gamma Brainwave Used in MIT Research to Prevent Dementia
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Published 2024-07-23
Studies at MIT and elsewhere are producing mounting evidence that light flickering and sound clicking at the gamma brain rhythm frequency of 40 hertz can reduce Alzheimer’s disease (AD) progression and treat symptoms in human volunteers as well as lab mice.
Why 40 Hz? Light and sound sensory gamma stimulation increases 40Hz power and synchrony in the brains of mice, that prompts a particular type of neuron to release peptides. These short peptide protein signals drive specific neuronal processes that promote increased amyloid and tau clearance via the glymphatic system. Because amyloid and tau protein buildup in the brain is one of the main findings in Alzheimer's dementia, reducing such "toxic" protein buildup is thought to possibly decrease risk for dementia development and potentially even treat it.
TED talk on this topic here: • Could We Treat Alzheimer's with Light...
In 2016, MIT researchers discovered that brain wave gamma frequency (40Hz) power and synchrony are substantially weaker in Alzheimer’s model mice and may also be in patients. They experimented in mice by stimulating gamma rhythms with completely non-invasive 40Hz flashes of visible light. In 2019, they showed that the flashes dubbed GENUS for Gamma ENtrainment Using Sensory, stimuli protected against neurodegeneration.
In 2019, the researchers showed that 40Hz sound stimulation works in mice too. They found that GENUS preserved both memory and cognitive performance..
In 2022, they published results of pilot Phase 1 and Phase 2A human clinical studies showing that audio and visual GENUS was safe, well tolerated and successful in increasing 40Hz power and coherence around the brain. Moreover, treated participants showed reduced brain atrophy, improved sleep patterns and improvement on face-name association memory after three months compared to untreated controls.
The results have been so promising, a new startup company, Cognito Therapeutics, has been created by the MIT researchers.
This video is for educational purposes only. Please consult your doctor before engaging in brain wave technology! Preliminary results suggest watching and listening for 1 hour every day.
Research
Multisensory gamma stimulation promotes glymphatic clearance of amyloid. Nature 627, 149–156 (2024). doi.org/10.1038/s41586-024-07132-6
Gamma frequency sensory stimulation in mild probable Alzheimer’s dementia patients: Results of feasibility and pilot studies. PLOS ONE. Dec 2022. doi.org/10.1371/journal.pone.0278412
Gamma Entrainment Binds Higher-Order Brain Regions and Offers Neuroprotection. Neuron. Volume 102, Issue 5, 5 June 2019, Pages 929-943.e8.
www.sciencedirect.com/science/article/pii/S0896627…
Multi-sensory Gamma Stimulation Ameliorates Alzheimer’s-Associated Pathology and Improves Cognition. Cell. Volume 177, Issue 2, 4 April 2019, Pages 256-271.e22
www.sciencedirect.com/science/article/pii/S0092867…
Video created by Dr. Christopher Chang:
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All Comments (3)
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Make sure the video settings are set to 2160p60!!! Or you will not see the 40Hz light flickering. You can have the video automatically loop as many (and as long) as you want. To loop, or automatically repeat any video, right-click the video or play button and select the Loop option from the drop-down menu. The light strobing and sound clicking at 40Hz (peak 10KHz). Lower frequency sound clicking centered at 10kHz can be seen/heard here: https://youtu.be/ZyOMipUT_1g TED talk on this topic here: https://www.youtube.com/watch?v=AS0K0XOMNwA
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Could you release a video at 30 min or an hour long to do the same length of exposure as done in the MIT study?
