THE HUMAN MICROBIOME: A New Frontier in Health
Published 2019-12-23
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0:00 Introduction
0:49 What We'll Cover Tonight.....
2:06 Microbes Pre-date Earth's Biodiversity
3:23 Culture-based Approaches do not Reflect the True Diversity or Physiology of Microorganisms
8:00 Enabling Tools to Interrogate Microbial Dark Matter
10:11 Humans are Superorganisms
11:12 The Gut Microbiome is Home to Several Trillion Microbes
12:22 Genetic Capacity of the Gut Microbiome Dwarfs that of the Human Host
13:48 The Gut Microbiome Evolves Over Human Lifespan
16:56 Human gut microbiome viewed across age and geography
19:07 Diet Rapidly and Reproducibly Alters the Gut Microbiome
21:52 Microbiome Perturbation Associates with Disease
22:38 The Gut Microbiome Influences Remote Organ and Immune Responses
23:47 Human Microbiome - a Lever on Host Physiology
25:58 Yellow Soup for the Soul!
30:55 Asthma is Prevalent in Westernized Nations
36:47 Gut Microbiome Manipulation Alters Airway Mucosal Response to Allergen Challenge or Viral Infection
38:18 Gut Microbiome Manipulation Alters Serum Metabolic Response to Viral Respiratory Infection
41:05 Gut Microbiome Influences Hematopoietic Cell Programing via Plasma-associated Mediators
42:52 How Could the Neonatal Gut Microbiome Influence Airway Disease Development in Childhood?
44:39 High-risk for Asthma Gut Microbiota is Distinct at Birth and Exhibits Delayed Development in Infancy
46:13 Wayne County Health, Environment, Allergy & Asthma Longitudinal Study (WHEALS) Birth cohort
47:04 Neonatal Gut Microbiota State is Associated with Risk of Childhood Atopy and Asthma
49:49 Human Immune Cell Assay to Assess Neonatal Gut Microbiome Immunostimulatory Capacity
50:46 High-risk Neonatal Gut Microbiome Induces Allergic Inflammation and Suppresses T-regulatory Cells
52:51 12,13 DIHOME Promotes Airway Allergic Sensitization and Increased Circulating IgE in Mice
54:09 Altered Linoleic Acid Metabolism Characterizes High-risk Gut Microbiota
55:17 Is the High-risk Neonatal Gut Microbiome Enriched for 12,13 DIHOME Production?
56:25 Neonatal Fecal 3EH Copy Number and 12,13 DIHOME Concentration Predicts Childhood Atopy and Asthma
57:33 Model for Childhood Atopic Asthma Development
59:40 Early-life Gut Microbiota Relates to Childhood Obesity and Overweight Phenotypes at 2 Years
All Comments (21)
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Check out "Picky Eaters: Convincing Immune Cells to Eat Cancer" here: https://youtu.be/92LeaeG96lc
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I received a FMT ( fecal microflora transplant) one month ago! I had a bacteria infection, took an antibiotic to get rid of it (C Diff bacteria)! I have no more C DIFF spores 🌝 Now that I have brand new gut bacteria, I am living ,and eating to feed THEM ❤ I feel like a new person mentally, physically, and spiritual!!!
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I'm a formula fed 70's child FUT2 non excretor. Suffered ADHD, numerous illnesses, addiction issues etc.. I'm finding health through organically growing my own vegetables with which to support my microbiome. Prolonged fasting has massively helped too as has cutting out alcohol, bread and vegetable fats. I make my own ferments and herbal extractions for digestive tonics. I fully subscribe to modulating your microbiome to help the physiology reach homeostasis.
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The speaker gave a fantastically well-organized and concise presentation! No off-topic rambling at all. This made it very easy to follow and stay focused on the information. Great job!
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One of THE BEST presentations on the impact of the human microbiome. She so clearly & concisely condenses this vital, newer field and its critical role in human health.
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As an infectious disease physician who has had an abiding interest in the health and disease implications of the human micro biome for several years, I almost skipped this presentation. So glad I didn’t! Great information, well-organized and communicated in a highly engaging and compelling manner.
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Sulfite intake is directly linked to asthma symptoms and urticaria. Sulfites are ubiquitous, as they are used as a fumigant, antimicrobial agent and bleaching agent in the manufacturing/processing of foodstuffs. In the U.S. ingredients of ingredients are not required to be listed on food labels. So you won’t see sulfites listed when they are used in the processing of food raw materials. The worst offender is high fructose corn syrup (HFCS). Sulfites are used as antimicrobial “preservatives” in high fructose corn syrup at 1000 times the level permitted by the FDA as an additive, but as an ingredient of an ingredient, it need not be disclosed. Compounding this problem is the fact that many pediatricians tell parents of asthmatic children to replace milk with juice - often containing high fructose corn syrup, thus heavily laden with sulfites. Sulfites are also used as a bleaching agent in regular sugar, flour and salt. So condiments and gravy and other flour products can be a problem. Sulfites are also used in the manufacturing process of all alcoholic beverages and all sugared beverages. Additionally, sulfites are found in all frozen seafood, to prevent black spots. The food technology industry has been allowed to become insidious in renaming high fructose corn syrup and even changing the manufacturing process, making it more potent and requiring more sulfites. There is information available on the internet regarding the tested content of sulfites in foodstuffs and the renaming of HFCS. If you, or someone you know suffer from asthma it’s worth the effort to research. Most of this information regarding sulfites became known because previously, restaurants were allowed to sprinkle metabisulfite on salad bar foods, e.g., greens, veggies, fruit, etc., resulting in more than a few asthmatics having immediate lethal asthma attacks. HTH!
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Wow. What a speaker she is. I watched this video 4 times and got answers to many of my questions about gut microbiome. Thank you for sharing.
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Very instructive presentation. This lady is gifted by such a harmonious voice and perfect diction that I would pay to listen to her reciting the content of the phone book.
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She is one of the best speakers I've ever heard. I can listen to her all day. Little bit of residual Irish brogue, but she's clearly been in SoCal for a long time. And doing great work!
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I have suffered from asthma all my life and have been doing everything I can to improve my lifestyle and diet to reduce my symptoms. This lecture is mind blowing and has completely changed my view on the disease. If there was ever an opportunity to take part in clinical trials I would jump at the chance. Until then the new topic of study is gut biome health. Thanks for this great lecture!
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What a pleasure to hear that proactive scientists are unraveling so many causes and interactions in our own body ecosystem. 👏
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Diet works to address inflammation. I’ve been a private health chef for 30 years and have seen positive results in 99% of my clients in their health journey.
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I am highly impressed ! Microbiome Science is in it's very beginning stage and has the enormous potential for application in treatment of ALL medical conditions. They are a true biomarkers of most deseases. I am full of admiration for Dr. Lynch for linking different ailments with different Microbiome diversity. These studies might be awarded with the Noble Price. It is already revolutionizing diagnostics.
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Simply fascinating! As a biomedical PhD student working on the Gut-Liver axis, the gut microbiome is extremely relevant for my research. I'm glad I convinced my PI to include a segment of experiments to check how the gut bacteria play a role in our models. Great things will come from microbiome research! It's still early days to come up with targeted therapies, but man, this is exciting research!
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For over a month I've been preparing home made keffeir a glass intially each day, now every second day. I include a healthy Mediterranean diet and I can't believe how much better I feel . This is good research presented by the lady. Thank you from Australia 🙌
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This PhD is weellll above average in the ability to communicate succinctly very complex topics. Bravo.
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Dr Lynch and staff.... Thank you. I will be following your research. The amount of human suffering that potentially will be avoided is unfathomable. Thank you.
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I would like to hear this professor's assessment of glyphosate, the ingredient in the herbicide Round Up. It kills the bacteria in our gut, on a daily basis. This is a call for the practical knowledge of this expert.
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It's so funny cos my sisters boyfriend (who has Colitis) reckons the doctor told them to 'not eat highly fibrous foods as their body cannot break it down and they should stick to refined stuff'. Goes to show a lot of doctors don't learn about nutrition and are just taught to prescribe drugs!
