Remyelination for Multiple Sclerosis [Clemastine]

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Published 2020-04-15
Start watching to learn about clemastine, the old anti-histamine drug which has the potential to remyelinate multiple sclerosis lesions.

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My book "Resilience in the Face of Multiple Sclerosis" on Amazon: www.amazon.com/dp/B07WP7H5LK

Selected Sources:

The legendary screening study for FDA approved drugs which promote remyelination (Dr. Jonah Chan):
www.ncbi.nlm.nih.gov/pubmed/24997607

The ReBuild Trial: Clemastine fumarate as a remyelinating therapy for multiple sclerosis

www.ncbi.nlm.nih.gov/pubmed/29029896

The ReCOVER trial:
www.nationalmssociety.org/Research/Participate-in-…
2017 Remyelinating therapies for MS:
www.ncbi.nlm.nih.gov/pmc/articles/PMC5722779/

M1 receptor mediates effect of clemastine: www.ncbi.nlm.nih.gov/pubmed/27671734

Clemastine reduces behavioral changes in socially isolated mice and enhances myelination in the prefrontal cortex:
www.ncbi.nlm.nih.gov/pubmed/26791223


Dr. Brandon Beaber is a board-certified neurologist with subspecialty training in multiple sclerosis and other immunological diseases of the nervous system. He is a partner in the Southern California Permanente Medical Group and practices in Downey, California (South Los Angeles). He has several publications on MS epidemiology and has participated in clinical trials for MS therapeutics. You can follow him on twitter @Brandon_Beaber where he regularly posts about MS news and research.

Follow me on twitter: twitter.com/Brandon_Beaber

Music: INNER GRACE - Copyright 2018 Wilton Vought

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The video material by Dr. Brandon Beaber is general educational material on health conditions and is not intended to be used by viewers to diagnose or treat any individual's medical condition. Specifically, this material is not a substitute for individualized diagnostic and treatment advice by a qualified medical/health practitioner, licensed in your jurisdiction, who has access to the relevant information available from diagnostic testing, medical interviews, and a physical examination. To the extent that Dr. Beaber endorses any lifestyle change, behavioral intervention, or supplements, the viewer should consult with a qualified healthcare professional to determine the safety and efficacy of the intervention in light of their individualized information.

All Comments (21)
  • @Lisa_P73
    Please do a follow up on this?
  • That seems very promising. As someone who has damage from prior optic neuritis, this seems like a step in the right direction.
  • @HurricaneHeather
    Had Optic Neuritis in 2008, was finally DX'ed in 2023 with MS after a major flare in my spine at C1-C2 gave me this intractable spasticity. Was given Clemastine (because I begged for it) in August 2023. Took 6 weeks worth and noticed a noticeable change in the center field of vision in the affected eye. Completed my 2nd year of discontinuous DMT with Mavenclad last month. Started up with Clemastine again at the beginning of this month. It's important to mention that I have had an eye exam after the first round and the correction in my left eye had to be reduced. If cog fog doesn't get me, I'll work to remember to come back here and tell you all what my anecdotal experience is/was.
  • @EChomkoful
    Thank you so much for making these videos. They are supremely intelligent and helpful. What are your thoughts on whether there are alternative therapies that may help demyelination, such as NAD+ infusions, or oral or sublingual ND/NMN? I would be interested in a video on this. Thanks again Doc!
  • @davezay5933
    This is a beautiful discovery and I hope it follows through and helps re-myelination and reversing damage caused by that whole multiple sclerosis process, hopefully big Pharma does this new gain in medicine and turn it into some other money game and we still suffer, this is where God will prevail just Gotta keep the faith!!
  • Thank you for making this video I have Multiple Sclerosis so see that resurrection has been done with this issue is the best thing to finding out a cure against this Multiple Sclerosis sickness. ( like a piece to this puzzle that needs to be found )Thank you
  • Is there any work to be done with clamastine? Please let me know. Thanks for making these videos, I was feeling depressed earlier, but your video gavee hope to live! Thanks doctor Beaber!
  • @vicbonilla9954
    This is very fascinating! What do you know about us who got HSCT and the ability to take this drug?
  • Always appreciate hearing about potential MS treatments that treat the damage done by MS. I am hopeful to recover some of what I have lost to MS. Thank you for sharing.
  • @mccorn75
    I enjoyed this video and found the research intriguing! I participated in the CombiRx Phase Iii trial circa 2005-2012. Wo hi of you be able to review the results of this study please? I did receive both treatments in the study and feel that the course of my disease was dramatically slowed because of early and aggressive treatment. I understand that DMTs are very expensive and no insurance company probably would not cover two therapies. However, I wasn’t able to find the results of this study. Thank you!
  • @Shasha8674
    LDN helps get rid of plaques in the brain. Vit B12 methylcobalamin shot with folate/progesterone/lecithin and more may help once gluten/dairy/soy/sugar/GMO are stopped. Vit D3/sunlight may help.
  • @allkeyspro6606
    Hi Dr Brandon. I suffer from a disease called AMN. It is a rare genetic nerve disorder. At present, there are 0 treatment options, and breakdowns of myelin are the big issue. Do you think this treatment might be a possibility for this disease?