Rat/Mouse Brain Hybrid Created: New CRISPR Method for Cross-Species Chimeras
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Published 2024-07-19
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Scientists grew a hybrid mouse with rat brain cells, using genetic modification and stem cells from a rat. Their new method for creating chimeras, based on CRISPR, could open the door to growing humanized organs in animals for transplantation into humans.
Note: Rat and mouse cortex is not wrinkly like human cortex. It is pretty smooth, as shown at 7:06.
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Link to paper (paywalled) www.cell.com/cell/abstract/S0092-8674(24)00308-8
Another video on chimeras: • Hybrid Monkey Breakthrough: A Step To...
Chapters:
0:00 Introduction
0:19 Blastocyst Complementation
1:39 New CRISPR Method
2:26 Forebrain Replacement
3:38 Staining the Brain
5:02 Interspecies Brain Hybrid
6:27 How Far?
7:05 Normal?
8:28 Persistent?
9:03 Synchronized Development
9:51 Cell-Autonomous Mechanisms
10:32 Human Organs in Animals
11:19 Limitations
11:37 Functional Connectivity
All Comments (21)
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Cat girls are coming, guys
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damn that's crazy. instead of thinking about cheese it was probably thinking about cheese
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1980: I bet there'll be flying cars in the future 2014: new rat just dropped
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You have a knack for dumbing down information without insulting anyone. This was a great and exciting video.
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My first tought was : "God if the Furies find this, we're in big trouble"
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Me: "ya can we have affordable housing" The world: "best incan do is rat mouse chimera!"
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Another step closer to Humans being capable of photosynthesis.
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Even thought I don't fully understand most of your videos I can't avoid finding them really interesting. Keep up the great work!
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The pinky, the pinky and the brain brain brain brain..
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This is mind blowing
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"So basically we genetically engineered a rat with body dysmorphia" '...why?' "it sounded cool"
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Is this a mat or a rouse?
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Mrs Frisby’s husband definitely had human brain cells.
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Damn, Jurassic Park for real.
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test which one is more dominant by seeing if it'll snitch
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reincarnation as a human in the future would be the ultimate punishment
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Technological horrors within my comprehension
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Ah yes, human horrors beyond our comprehension.
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Cool mate , I want a talking t-Rex in my backyard.
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Is this a similar concept to how Killer Bees didn't used to be part killer?
