The most exciting REAL anti-ageing drugs
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Published 2023-08-31
Or watch more longevity videos in my playlist: • Aging
Chapters
00:00 Introduction
00:46 Rapamycin
02:34 Senolytics
04:49 Metformin
06:18 Taurine
07:24 Statins
09:54 Conclusion
Sources and further reading
If you want to know more about rapamycin, this @mattkaeberlein4086 video is a longer introduction to the science behind it • Rapamycin is the gold standard for lo...
And, if you want to know much more about metformin (and a bunch of other cool longevity science), you might enjoy Nir Barzilai’s interview with @TheProofWithSimonHill • Slow Aging with a Pill? | Nir Barzila...
Rapamycin
Review of the evidence for rapamycin, rapalogues and other mTOR inhibitors in humans www.sciencedirect.com/science/article/pii/S2468501…
Phase 2b and Phase 3 trials of rapamycin-like drugs for improving immunity in older people www.thelancet.com/journals/lanhl/article/PIIS2666-…
Senolytics
2018 paper giving D+Q to old mice www.nature.com/articles/s41591-018-0092-9
A great overview of the dozens of companies currently working on senolytics www.nature.com/articles/s41587-020-00750-1
Metformin
Study showing people with diabetes taking metformin outlived ‘healthy’ controls dom-pubs.onlinelibrary.wiley.com/doi/10.1111/dom.1…
Taurine
More information and links in my Twitter thread on the results twitter.com/statto/status/1667075657874939907
The paper (sadly paywalled) www.science.org/doi/10.1126/science.abn9257
Statins
Effect of statins on all-cause mortality in adults: a systematic review and meta-analysis www.mdpi.com/2077-0383/11/19/5643
General
A recent paper from the Interventions Testing Program (ITP), with an overview of its successes so far: ‘Six compounds have thus far produced significant extension of life span in ITP studies in 1 or both sexes: rapamycin, 17α-estradiol (17aE2), nordihydroguaiaretic acid (NDGA), Protandim, glycine, and acarbose.’ (This paper adds Canagliflozin to the list.) www.ncbi.nlm.nih.gov/pmc/articles/PMC7710304/
Calculations for risk of diseases with age can be found at github.com/ajsteele/ageless
Oh and btw, I’m British so I normally spell it ‘ageing’ just in case anyone’s searching for ‘anti-ageing’. Some people call this field of science biogerontology, geroscience or longevity research.
Credits
Stent animation CC-BY BVM Medical commons.wikimedia.org/wiki/File:Stenting_of_Coarct…
Mice on a treadmill CC-BY Aderbal Aguiar • Running mice in treadmill
Atherosclerosis progression diagram CC-BY YitzhakNat commons.wikimedia.org/wiki/File:Artery_with_athero…
Neutrophil diagram CC0 Mrmw commons.wikimedia.org/wiki/File:NeutrophilerAktion…
And finally…
Follow me on Twitter twitter.com/statto
Follow me on Instagram www.instagram.com/andrewjsteele
Like my page on Facebook www.facebook.com/DrAndrewSteele
Follow me on Mastodon mas.to/@statto
Read my book, Ageless: The new science of getting older without getting old ageless.link/
All Comments (21)
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Edit: For everyone commenting that I forgot exercise…you might enjoy this video: https://youtu.be/9H40yatCwo0 :) If you just want the lowdown on a specific drug…check out the video chapters! 00:46 Rapamycin 02:34 Senolytics 04:49 Metformin 06:18 Taurine 07:24 Statins And, if you want to know more about these and many more longevity drugs, you might enjoy my book, Ageless ageless.link/ or my playlist of aging biology videos youtube.com/playlist?list=PLg0VbZ0kyCHmO8iGdXdg_Fu…
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This is very exciting because I am a mouse
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My top 5 would be: 1. Pursue happiness 2. Alleviate Stress 3. Exercise 4. Eat Healthy 5. Being Mindful
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Fun fact: Andrew is 103 years old.
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Exercise. Exercise is the best thing for antiaging.
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As a statin user from age of 17 until now 29.5 and hardly research that thing I would advice you to check the negatives of statins on humans who take them for a long period. I take it because I have to but I wouldn't touch it otherwise
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Alpha-Ketoglutarate appears to be a promising anti-aging drug (it has increased lifespan in studies on worms and mice). Another is the combination of the amino acids glycine and n-acetyl cysteine (often referred to as GlyNAC), which increases levels of endogenous glutathione. I would welcome your thoughts on these in a future video.
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Great content Andrew! I like your informative optimistic style of delivery and still present any negatives our counter arguments that should be addressed
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Thanks for the vid, Dr Steele! Suggestion for the future topic is eating related interventions for longevity, as far as I saw, you didn’t cover it on your channel. Complete fasting for multiple days vs intermittent fasting vs longterm low calorie diet vs fasting mimicking diet vs keto diet vs macronutrients manipulations etc. There are many proponents for each of these strategies, but I didn’t saw any deep enough comparison.
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IMF 18-6 works best for me. Have been on this fasting diet for over 2 years. No sugars whatsoever. 100-200 grams per day max of complex carbohydrates ( Brown rice, multi grain Schwartz Brot, whole grain pasta). Semi - Keto diet. Fish, seafood, eggs pescatarian. Almost 63 yrs young. Perfect health! No pills whatsoever. Low glucose, normal colesterol, low blood pressure, low heart rate. Also, 15 minute HIIT every morning . ❤
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The much insulted method of intermittent fasting removes senescent cells through autophagy and doesn't involve taking drugs. You also lose weight, lower blood pressure and sugar, as well as a load of other improvements. "Take a pill for it" should be a last resort.
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Have any studies shown that berberine can be used in the place of Metformin? I realize that Metformin has been established to exhibit anti-aging properties because it is synthetic and money can be made on Metformin. Berberine on the other does have similar properties but is a natural compound found in a number of plant species. Therefore there is little incentive to make any money on the sales of berberine which is available OTC. It does exhibit less side effects than Metformin according to reports in the literature. I generally take berberine in a formulation combined with medium chain sized fatty acid oils. Please comment if you know of more information about berberine. Thank you.
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Here hoping real progress is developed here. The case that ageing is one of the most pressing human causes of suffering and death, especially in wealthy societies where easier problems have been solved, has convinced me.
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Problem with statins as anti-aging: although statins do reduce ldl cholesterol, the hypothesis that ldl cholesterol is the cause of heart disease has been falsified. In fact people with high ldl tend to live longer than people with low ldl, because ldl appears to have immune system functions protecting against infection and cancer.
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1. calorie restriction [ keeping a good weight ] 2. adequate sleep, low stress 3. Aspirin 10mg 3x a week 4. low dose stain twice a week, Crestor 5. Metformin daily 6. Jardiance daily
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Could you please look into peptides. I had problems with pain in my shoulder and hip for 1.5 years, trying everything, nothings worked. I ordered the peptide bcp 157 in tablet form. I took them for a month, and the pain is gone. I would be very interesting to hear what you think about peptides.
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Gimme the cocktail please. Time is running out.
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Pills can help, but nothing can replace good ol' sleeping cold, HIT exceecise, maintaining endurance fitness at old age, diversifying sources of protein intake, and eating more micronutrient & antioxidants-rich foods.
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hi,great video,i would like to know what is the opinion about urolthin a as an anti- ageing supplement.
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Hi Andrew, thanks for doing this video! Two questions: 1) Due to the dietary sources of Taurine, do you think that considering Taurine supplementation may be especially interesting for strict vegans (like myself)? 2) What is your take on (taking) Alpha-Ketoglutarate?