Osteoporosis Medicine: Overview by Endocrinologist Dr. Janet Rubin

Published 2021-04-04
In this interview, I ask endocrinologist and osteoporosis expert Dr. Janet Rubin to discuss osteoporosis medicine and the various pharmaceutical alternatives for people at risk of a fracture.

-Chapters-
0:00 Introduction
1:18 Osteoporosis Medicine and Bone Remodelling Process
4:08 The Role of Bisphosphonates (Historical Perspective)
11:42 Are Osteoporosis Medicines Prescribes to Women in Their Fifties?
15:12 Risk of Fracture When Stopping Osteoporosis Medicine
17:44 Should a Patient Request a Specialist for Osteoporosis Medicine?
22:14 Risk of Osteoporosis Medicine Side Effects
27:33 Reduce the Risk of Osteonecrosis of the Jaw

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ABOUT DR. JANET RUBIN, MD

Dr. Janet Rubin is the Sarah Graham Kenan Distinguished Professor and Vice Chair for Research at the Department of Medicine of the University of North Carolina in Chapel Hill. She is also the Professor of Medicine in the Division of Endocrinology and Metabolism, a Joint Professor in Pediatrics and Pharmacology, and Adjunct Professor for Bioengineering.

Dr. Rubin is not only a Professor of Medicine and researcher, she has a busy clinical practice treating patients with osteoporosis.

Dr. Rubin has been investigating bone remodelling for decades. Her particular focus has been on how exercise and mechanical force affects the cell cytoskeleton.

Since 2008 Dr. Rubin has been recognized by her peers as the best Doctor in America.

Medical Disclaimer
All the information, content, and material presented in this video is for informational purposes only. It is not intended to serve as a substitute for the consultation, diagnosis, and/or medical treatment of a qualified physician or healthcare provider.

All Comments (21)
  • That was all very interesting, thank you. One thing I dislike a lot is when professional people call the stopping of potentially harmful drugs a "holiday". It is nothing like a holiday, waiting to see how much your bones deteriorate before being put back on the drug. It's condescending to have people call this time a "holiday".
  • @deetin3658
    My mother-in-law is a 100 years old. Never went on this kind of medicine, she was always walking. Cause she worked in the hospital for 53 years. She's a 100 so far so good. She hasn't broken anything.
  • Incredible physician you have interviewed here! Thank you to you both!
  • This is the best video on drugs for osteoporosis ! Just the facts vs scare stories. Please have this Doctor Rubin back for more info. She is fantastic. Thanks !
  • @KS-wn5vc
    Best information to date on osteoporosis. As a pharmacist and patient, this is so timely and helpful. There are very few doctors so specialized. The aging population of baby boomers needs more practitioners like Dr. Rubin and physical therapists like Margaret. Thank you very much! I have hope that I can do something about my dire genetics and very poor bone density. Please provide updates on Evenity as more is known. Thanks again
  • @vivian9803
    None of this is reassuring. I just received a diagnosis of osteoporosis and I’m 65. As much as I’m concerned about the prognosis of that diagnosis, I’m more terrified and wary of treatment with these drugs.
  • @lindafarris7363
    Margaret I appreciate so much the series of information on prescriptions for bone loss. I am learning what my questions are before I see my doctor next month. I've been trying to figure out if there are actual bone specialists. But it seems like there are doctors and physiotherapists who have specialized in osteoporosis. Thank you for helping to empower me as a patient.
  • @spiralflash6169
    Thank you, Margaret, for all your fantastic work on osteoporosis. As a "young, old" woman who had been on bisphosphonates for 9 years, then a holiday for 3 years with regression, and reluctant to go back on the drugs, I find this presentation invaluable. With a good education on all the details and nuances, we are able to come at this condition from a spirit of collaboration instead of fear! Thanks again.
  • @tygywoo
    I feel like she glosses over the GI side effects of some of these drugs. I took Fosomax for several years but the heartburn that it caused made me absolutely miserable on a daily basis. That's the reason I haven't started up on another drug treatment despite my DEXA numbers getting progressively worse.
  • Just turned 75 and my pcp said my DEXA showed osteopenia and prescribed Fosamax. I read about the side effects and was shocked to realize that my mom who had been on Prolia for two years got osteonecrosis of the jaw and her teeth loosened with no bone around some of them! Fosamax warned of the same side effects! No thanks to that poison! I’m increasing my weight training, taking a bone supplement and just got a vibration platform. And praying for a reversal.
  • Thank you, @Margaret Martin, Physical Therapist, for persisting in this conversation and asking the questions that your experience with patients leads to. The answers we get here are so much more thoughtful than the usual run of the mill -- particularly those produced by pharmaceutical companies!
  • @majaber1
    Thanks for uploading this video...the bone specialist dr is so refreshingly honest and frank about drigs benefits limitations and the fact that docs dont know everything.
  • @54Lily
    Dr.Rubin, thank you. I'm a 'young-old', been on Prolia for 5 years. Information from my Endocrinologist is 'sketchy' at best. Your presentation was calming and informative. It will help me formulate my questions for my next visit. I don't feel so alone when it comes to osteoporosis. If I could ask a question, does Prolia help with osteoarthritis? Perhaps another video to address that one. Many, many thanks for bringing so much information to light.
  • I'm 56 and fell and had to have a hip replacement I was diagnosed ostoprosis ,this interview was just what I needed . I now feel confident about the medication I'm taking. I have my holidays planned in 5 years . I also have started taking estrogen. You really have made a positive impact on how i feel about my condition. Thank you .(from the UK)
  • @lisad.3247
    Excellent video. I now have a better understanding about taking Prolia. Thank you so much!
  • @marmaz57
    Thank you Margaret and Dr. Rubin. I so appreciate this important information. Bless you.
  • Thank you very much. This was an excellent presentation. Very grateful.
  • I so much appreciate what you have done for us - I’m 76 with osteoporosis, drug-free so far - in bringing information which goes a long way to dispel fears. My primary wants me to take Fosamax and I need to be sensible. Thank you.
  • I took biphos and suffered severe muscle pain. It was 8 years ago. Recently, I was offered Prolia, and after 1 shot, I developed bone spur in my spine which required surgery due to nerve pain . Also bone pain to the arm presented. I stopped the Prolia regardless what benefits it promised. The benefits are in the future but the side effects are now. I don’t see any documents mentioned the side effects I have endured
  • @barbh6987
    Wow this interview has helped me so much, thank you! I was reading all these terrible results from Fosamax and I had really considered not getting it. I'm 67 and was diagnosed osteoporosis in 2022. So I will be probably going ahead starting it this summer. It will be an infusion so I hope my doctor can see if I'm having a bad reaction to take care of me. Don't know how that works. My doctor is at a college hospital in Chicago so I guess he sees lots of patients and will know what to do. Thank you do much for helping to relieve our anxiety.