Methotrexate (Rheumatoid Arthritis Drug)

A friend of mine suffered from this at the age of 35, it took about a year to get the diagnosis. You could always see he was in permanent pain and then they have him this treatment and it was like night and day - you could see him just relax. The difference was incredible.

This video has hardly been out an hour and friends are already sending this to me. Thank you for explaining one of the drugs I take, it feels better to have a stronger understanding of what it is and does.

Having this at 24 really sucks… praying for all of yall to feel better.

i just went to the doctor yesterday because of arthritis symptoms, swelling, crooked fingers, & weak joints. thank you so much for posting this, it really helps me understand the condition and not be so afraid.

My partner was on Methotrexate, it nearly killed him. Our GP was quick to get him into hospital when his blood test results suddenly went haywire. Meds were changed and his rheumatoid arthritis is much worse now, but at least he’s still alive.

Very interesting video!! I had methotrexate therapy when I was 28 and again when I was 34 to help manage my autoimmune disease (granulomatosis with polyangiitis). I’m very grateful for the science that made this possible.

As a nurse this makes for an amazing review and helps me daily to care for my patients. Thanks professor Dave

My rheumatologist FINALLY convinced me to start this last year at 50 after decades of RA pain - I cannot believe the difference. When I was prescribed it, I had a few people and the pharmacist recommend that I not take it since it is deadly 😒....glad I didn't listen.

I was diagnosed with RA at the age of four and I started methotrexate at 6 up until 14. Although methotrexate helped me, the side effects were hell. I’m 26 now and it’s interesting to see and understand the science behind this drug that I used to take soo often. Although I don’t see myself ever going back on this drug, I love to see how much it has helped people because this condition is no joke. I wouldn’t wish an RA flare up on no one!

As someone who suffers from RA. I am on Methotrexate, the Folic acid supplement and Prednisone. Before I was on these drugs, I was in Chronic pain and barely able to move let alone do anything like, Work, Walk, Cook, Clean etc etc. Just 3 days after I started treatment I was able to live a full life again. These drugs are a "miracle" (If there is such things) and it made my love and confidence in proper scientific medicine so much deeper and profound.

I just want to say thank you so much for these videos, I have ADD and it makes it really hard for me to concentrate on subjects like these, but somehow you've made it easy enough for me to understand. Thank you again, love this channel!

Some years ago, I lost my mother to Methotrexate. Due to an error in anamnesis at the beginning of what was planned to be a minor short-term stay in a renowned Austrian hospital, her weekly arthritis-stabilizing dose of MTX was given to her as daily dose. The OD led to effects like an uncontrolled chemotherapy (which it actually was); her bone-marrow was completely destroyed, her immune-system broke down, she had to be reanimated and for the remaining horrible months of her life she had to be tube-fed and most of the time artificially respirated. Even though I know, that her death was not the "fault" of this drug, but the consequence of medical malpractice, I was triggered by this praise of Methotrexate as an antiarthriticum beyond my limits...

I have had RA for 22 years. Initially was diagnosed with lupus and found out in March of 2023 that I actually have rheumatoid arthritis…long story. My new doctor wants to take me off of hydroxychloroquine (which has never given me any issues) and put me on methotrexate. She gave me 90 days to decide. During that time, I decided to eliminate gluten, watch sugar, do intermittent fasting and increase my Vitamin D. I’m taking 4000 iu of Vitamin D plus I take a multivitamin which has 1000 iu. I noticed an immediate difference after increasing my vitamin D. My biggest complaint is having one or two stiff fingers when I wake up, and I refuse to take methotrexate for those symptoms.

I am a 31 year old RA patient. I have been taking methotraxate and folic acid for years now. I wish I found this explanation earlier as nobody explained how essential taking folic acid is.

A relative of mine took methotrexate and wound up passing in their 50s from RA complications. It does not work for everyone. She was racked with pain and the RA effected her vital organs. It might work for mild arthritis for a while. She told me the methotrexate caused her to be very tired.

This was an extremely useful video for us as my wife is currently on methotrexate one tablet once a week, for a very rare skin rash, that did not respond to any other treatments. Many thanks for this explanation of the drug it is a big help, and far better than the doctor's "Erm take this anti cancer drug for a year, it will cure you but you need blood tests every week and mri scans every six months !"

My daughter was diagnosed with RA at 19, which made us realize she’d had it a lot younger from the symptoms of her past. She ended up doing a program dietarily and is not on any RA drugs. She follows a strict dietary guideline and stays in remission. If she goes off of it, the symptoms return. Its far better at this time, then to be on methotrexate, which the side effects can cause infertility and other problems or the body forming a resistance to methotrexate. Then, trying to switch to other methods, like expensive biologics that aren’t necessarily covered by insurance. Its probably one of the worst diagnoses next to cancer. Science finally caught up with understanding that there is a gut problem connected to the joint flare ups. But, they don’t know if the gut problem is part of the disease or the other way around. We know its genetic and the gene gets switched on. Once that happens, you have RA for the rest of your life. My hope is that developments with CRSPR could possibly suppress the expression of RA. That said, I’m not anti drug. If you have severe flare ups, the joint damage is irreversible. If you need the drugs to knock that inflammation out of the ball park, then don’t hesitate to do so.

im going to use this playlist to help me in pharamcy tech training

Thank you for explaining how this works, I've been curious about its specifics for a long time, especially since when you get properly sick by something else you are allowed to skip a week of methotrexate to bounce back more easily. I've been taking both methotrexate and hydroxichloroquine for 4 years now since I was diagnosed with RA in early 2020. Whenever the doctors try to wean me off either my symptoms come back unfortunately. But for now I'm not complaining. I'm still young and at least I have my mobility. For the fellow users in the comments: another typical methotrexate side effect (especially if you take more than let's say 20mg per week) is mouth ulcers. They can be a real pain. Also not sure if it's an RA side effect or a methotrexate side effect but you might become more prone to yeast infections as well.

I take this drug. It took a long time to build up enough to begin feeling the therapeutic effects (approximately 6 to 8 weeks) but it has really helped a lot. Thank you for helping me understand this better. I'm going to review this with some of my science interested buddies to see if I can explore this a little further.