Epstein-Barr Virus Causes Multiple Sclerosis! [US Military Longitudinal Study]

Published 2022-02-02
An incredible case-control study from Harvard provides strong evidence that Epstein-Barr Virus, the cause of mononucleosis ("The Kissing Disease") causes multiple sclerosis. I also review 3 potential treatments of EBV which could benefit people living with MS in the future.

The study I am discussing:

Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis: www.science.org/doi/10.1126/science.abj8222


Other Sources:

Temporal Relationship Between Elevation of Epstein-Barr Virus Antibody Titers and Initial Onset of Neurological Symptoms in Multiple Sclerosis: jamanetwork.com/journals/jama/fullarticle/200953



Tenofovir prodrugs potently inhibit Epstein–Barr virus lytic DNA replication by targeting the viral DNA polymerase: www.pnas.org/content/117/22/12368

Tenofovir Alafenamide for Treatment of Symptoms and Neuroprotection in Relapsing Remitting Multiple Sclerosis: clinicaltrials.gov/ct2/show/NCT04880577

Moderna’s vaccine trial: trials.modernatx.com/study/?id=mRNA-1189-P101

Phase 1/2 Study to Evaluate the Safety and Efficacy of ATA188 in Subjects With Progressive Multiple Sclerosis (EMBOLD): clinicaltrials.gov/ct2/show/NCT03283826

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My book "Resilience in the Face of Multiple Sclerosis" on Amazon: www.amazon.com/dp/B07WP7H5LK

Dr. Brandon Beaber is a board-certified neurologist with subspecialty training in multiple sclerosis and other immunological diseases of the nervous system. He is a partner in the Southern California Permanente Medical Group and practices in Downey, California (South Los Angeles). He has several publications on MS epidemiology and has participated in clinical trials for MS therapeutics. You can follow him on twitter @Brandon_Beaber where he regularly posts about MS news and research.

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he video material by Dr. Brandon Beaber is general educational material on health conditions and is not intended to be used by viewers to diagnose or treat any individual's medical condition. Specifically, this material is not a substitute for individualized diagnostic and treatment advice by a qualified medical/health practitioner, licensed in your jurisdiction, who has access to the relevant information available from diagnostic testing, medical interviews, and a physical examination. To the extent that Dr. Beaber endorses any lifestyle change, behavioral intervention, or supplements, the viewer should consult with a qualified healthcare professional to determine the safety and efficacy of the intervention in light of their individualized information.

All Comments (21)
  • @huntstag7673
    I shed tears watching this. I always thought the idea that the immune system would just randomly go after the cns as an absurd idea. Thank u for sharing dr. Baeber
  • @Dddonalddduckkk
    Had EBV and Mono for months back when I was 16. Diagnosed with MS at the age of 33, but first symptoms started 10 years prior to that...
  • 👋 Hello Dr. Beaber what are your thoughts on bovine lactoferrin consumption? 📣 - Immunomodulatory - Anti-viral - Regulates intestinal permeability EBV Study: LF prevented EBV infection of primary B cells mediated by its direct binding to the EBV receptor (CD21) on the B-cell surface. **See next comment. (character limit, forces me to break these up)
  • MS has some strong link with stress. Because i had no symptoms until last years when i suffered severe stress January last year in december i was diagnosed with optic neurtis . MRI shows a lesion in periventricular region 5mm size and in lesion juxtacortical region. OCB test says tha band are present in both blood serum and spinal fluid.
  • @amyfarrow9981
    I had severe mono at 23 and was diagnosed with MS at age 37…this discovery is fascinating and I hope the vaccine for EPV changes MS for the future!
  • @arisarg1989
    I also have read the research, and i was informed that moderna is trying to develop an EBV " vacine " based on MRNA tecnology to eradicate the virus. My question is how is this gonna help people who already have been diagnosed with the disease and have symptoms? What could they expect ? ( I have been diagnosed with ms 3 years ago ).
  • @emilyanne4008
    I had mono as a teen and now have MS. I wonder if they should be monitoring titers of EBV now to get those with higher levels preventative treatment
  • @TL-ch1xd
    I grew up in a tick area (had two ticks/nymphs at two points as a child). I had EBV and a severe case of Mono which had me bedridden and ”half dead” for months when I was 15. Then I had a noticeable case of CMV in my early 20’s. And after that it went completely downhill for me. I developed Severe M.E. and have been trying to battle this illness now for 15+ years. I have days and weeks that are slightly better (when physical and mental torture is less and I can actually write and think and participate for a few hours). I just had Covid for three weeks and now all my M.E. symptoms are way out of control again with feelings of sinusitis (but in my brain), severe POTS, abnormal heart rate and uneven heartbeatings, personality changes - besides all my other M.E. symptoms that are always there. I have not MS, but ME. And yes, I have gotten slightly better and lessen some symptoms with extremely strict diet which among other things exclude sugar, gluten and milk products (I’ve gotten so much worse those times I’ve tried them again). Also doing antiviral herbs and raw food vitamins has helped me be able to get my thoughts together, my speech and ability to write back. I need to do Pacing (do as little mental and physical activities as possible - or I get much worse again and turn into a person who only lays in a silent dark room for weeks). Now, when I feel I can, I do gentle Qigong and deep breathing techniques. Coconut water (magnesium and potassium are good for POTS. Keltic Seasalt, water. I’m crashing as I write. I have a lot of advices on what can help somewhat for at least M.E. But I must rest now. Even if it might sound corny: Wishing everyone better/good health, love and peace. 💜👋☺️
  • @hamcki
    could you measure sNFL to see if you got activity or is it not the way to go and too expensive?
  • @alexthomas3902
    Will an EBV vaccine help an already affected MS person ?
  • @s0phian0va
    Thank you for these videos! I was infected with mono when I was 15 and at 30 I was diagnosed with MS. I am happy to hear there are studies underway and I’m looking forward to more effective treatments!
  • Hi Dr. B my son has MOG and presented with TM. He also tested positive for EBV I am wondering if we will find a link to MOG and EBV. I know MOG and MS are different but similar.
  • Thank you for all of your videos. Any info on Evusheld, especially for people on B cell depleters?
  • I have never been diagnosed with mono, but I was definitely exposed many times in my high school years. Annnd I don’t know the statistics but quite a few women I’ve met in support groups had their MS start up after giving birth, can pregnancy reactivate the virus?
  • @anagongs6353
    Hi- I don’t remember having mono- my EBV results was greater than 600k- any DMT that will beneficial for us now? Do you do any telehealth consults? - hello from Florida - glad to have found you!
  • @roberture5903
    Good morning doctor Brandon, thank you for doing this video. It was excellent. At the age of 55 I honestly don't know if I ever had EBV but I do recall somewhere in my late teens and early 20s I experienced major fatigue and sleepiness and often wondered if that was related. Could this be a question I could pose to my neurologist? It's so ironic that doing doing a video on this because there's also been some articles on it lately. Also I just lost the love of my life of 31 years last week and not long before she passed away she had asked me do you think you ever had the EBV virus. Again I want to thank you for this one and yes if there ever was a possibility I would love to take a treatment to shut this disease down or at least quiet it. Thank you for reading my long-winded message and I always enjoy listening to you because to me you're not just a doctor but a friend also. Until next time take care and have a great day.
  • @dermlover1
    What is the best blood test for chronic infection? EBV IgG and/or EBV nuclear antigen (EBNA)?
  • @mastringminds
    How can one know if u have it, i k ow many people measured negative and still have ms
  • @mrkkinman
    Hey, Dr. Beaber -- my wife has 24/7/365 vertigo with her MS. She's tried motion sickness medications with no effect. It's so bad, the dizziness often takes her breath away and the associated nausea impacts her ability to eat. Any suggestions to help impact this? We're pretty desperate and open to anything. We appreciate all you do for the MS community!