7 Ways To Boost Mitochondrial Health To Fight Disease

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Published 2023-12-04
Mitochondrial dysfunction is at the root of many diseases ranging from cancer to diabetes. This video explains how mitochondria are involved in our health, and shows 7 ways to keep our mitochondria healthy to help prevent disease.

www.ncbi.nlm.nih.gov/pmc/articles/PMC9441677/

www.ncbi.nlm.nih.gov/pmc/articles/PMC7749612/

www.ncbi.nlm.nih.gov/pmc/articles/PMC4478283/

www.ncbi.nlm.nih.gov/pmc/articles/PMC10045244/

www.ncbi.nlm.nih.gov/pmc/articles/PMC4156924/

academic.oup.com/biomedgerontology/article/61/7/65…

onlinelibrary.wiley.com/doi/10.1002/ddrr.108



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All Comments (21)
  • @LTPottenger
    Simply eating beef can boost your mitochondria as stearic acid from beef and taurine have amazing benefits for mitochondria, but nothing is going to help with your mitochondria and help prevent cancer more than doing some fasting! The many benefits of occasional extended fasting and lowering dietary carbs: Your body recycles up to 1/3 of all immune bodies in a 72h fast, rejuvenating your entire immune system. This helps with autoimmune disease, cancers and cytokine storm. Fasting stimulates phagocytosis, the ingestion growths pathogens and plaques by macrophages and other immune cells. This will remove spikes quicker, whether natural or unnatural in origin! Fasting and low carb help with POTS, which is driven by high insulin and blood sugar. Clotting and fibrin are inhibited, stopping any 'unusual' clots. Fibrosis aka scarring is reversed over time, including in the heart, lungs and clots. When insulin is high, vit D stays locked in the blood cells but fasting quickly lowers it. Vitamin D plasma levels are increased as fasting improves metabolic health, and vitamin D in turn increases autophagy. Fasting restores NAD+ and increases nitric oxide release to open blood vessels. Reflexes and short term memory are increased. Fasts from 36-96 h increase metabolic rate due to norepinephrine release!. Blood sugar and insulin are lowered when fasting, reducing inflammation and allowing the immune bodies to move freely through the body. T cells and T reg cells are vital in fighting cancer, autoimmune disease and infections. With age, the thymus stops making as many of them but fasting releases stem cells, which then can become new T cells. It also releases growth hormone, which regenerates the thymus itself! Fasting increases anti-aging Yamanaka factors and increases average telomere length in stem cell pools. Fasting can help with MS, Depression, BPD, Autism and seizures. When you move out of MTOR your body shuts down the building blocks of the cell required for viruses to replicate. The hunger hormone ghrelin also lowers with extended fasting and rises from dieting. What breaks a fast? Anything with protein or carbohydrates in it will break a fast but most teas and herbs are OK. Supplements and meds often break ketosis directly or contain a filler that will. Many meds are dangerous to take while fasting. Does fasting lower testosterone? No, it raises it when the fast is broken by increasing lutenizing hormone. Fasting also increases insulin sensitivity, which helps with muscle building. Fasting activates autophagy (literally self eating), which causes cells to recycle damaged proteins and foreign matter such as viruses. Lowering insulin via fasting virtually eliminates chronic inflammation in the body. Weight loss from daily caloric restriction has 1/4 to 1/3 of the weight lost as lean tissue while many studies show fat loss from 36 h fasts without losing any lean tissue! The obese will lose loose skin while fasting, but the frail will have increased growth hormone release, which helps to make more lean tissue and reduce frailness. Fasts of 36-96 will not affect short term female fertility or affect menstrual cycle. They also may increase long term fertility for some women. It increases mitochondrial function and repairs mitochondrial DNA. Good mitochondrial function also has the added benefit of increasing your metabolism, fighting infection and cancer prevention! 24h of fasting can cut your leptin levels in half! This reduces leptin resistance, which impairs immune function. Your brain prefers to burn ketones at a rate of around 2.5 to 1 when they are available in equal measure to glucose. Except for brief periods of very intense exercise, your body mainly burns fats in the form of free fatty acids. Fasting increases telomere length, negating some of the effects of aging at a cellular level. Fasting releases BDNF and NGF in the blood. This stimulates new nerve and brain cell growth, which can help a great deal with diseases like MS, peripheral neuropathy and Alzheimers. When not in ketosis, the brain can only burn carbohydrate, which produces a great deal of damaging ROS the brain has to deal with. Fasting stimulates apoptosis in senescent or genetically damaged cells, destroying them. Senescent cells are responsible for many of the effects of aging and are a root cause of the development of cancer. A fasting mimicking diet for 3-5 days in a row provides many of the same benefits as water fasting. FMD usually has 200-800 calories, under 18 g of protein and extremely low carbs. Exogenous ketones can aid with fasting, allowing some people with specific issues to fast in spite of them without worrying as much about hypoglycemia. They also help with dementia and many other issues even if you take them while not fasting! Glycine and trimethylglycine can also be useful supplements while fasting that won't break ketosis and have many benefits. Children, pregnant or nursing women should not fast for periods longer than 16 hours. People with pancreatic tumors that excrete insulin or certain rare forms of hypoglycemia generally cannot fast at all or only with doctor supervision. Type 1 diabetics can also fast but it is more complicated and should be approached with caution as it could lead to ketoacidosis and done under doctor supervision. If you experience extreme symptoms of some kind, especially dizziness or tremors, then simply break the fast with a low carb meal. Resources: https://www.nia.nih.gov/news/research-intermittent-fasting-shows-health-benefits https://pubmed.ncbi.nlm.nih.gov/31890243/ http://www.sciencedirect.com/science/article/pii/S0005272806000223 https://www.ncbi.nlm.nih.gov/pubmed/23876457 https://www.sciencedirect.com/science/article/pii/S1931312809002832 https://www.ncbi.nlm.nih.gov/pubmed/10859646 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093158/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895342/ http://www.cell.com/cell-metabolism/abstract/S1550-4131(15)00224-7 https://pubmed.ncbi.nlm.nih.gov/2518860/ https://www.ncbi.nlm.nih.gov/pubmed/24905167 https://www.nejm.org/doi/full/10.1056/NEJMc2001176 https://pubmed.ncbi.nlm.nih.gov/31877297/ https://www.ncbi.nlm.nih.gov/gene/25712 https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.121.17852 https://www.clinicaltrials.gov/ct2/show/NCT04375657 https://pubmed.ncbi.nlm.nih.gov/20102774/ https://n.neurology.org/content/88/16_Supplement/P3.090 https://pubmed.ncbi.nlm.nih.gov/6859089/ https://repository.upenn.edu/cgi/viewcontent.cgi?article=1537&context=edissertations https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779438/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407435/ https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30605-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1097276518306051%3Fshowall%3Dtrue https://pubmed.ncbi.nlm.nih.gov/28235195/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815756/ https://medicalxpress.com/news/2022-10-treatment-pulmonary-fibrosis-focus-telomeres.html https://www.cell.com/cell/fulltext/S0092-8674(19)30849-9 https://clinical.diabetesjournals.org/content/36/3/217 https://www.ncbi.nlm.nih.gov/pubmed/25686106 https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2265.2005.02288.x https://academic.oup.com/ajcn/article/81/1/69/4607679 https://www.amjmedsci.org/article/S0002-9629%2815%2900027-0/fulltext https://www.collective-evolution.com/2017/05/16/study-shows-how-fasting-for-3-days-can-regenerate-your-entire-immune-system/ https://pubmed.ncbi.nlm.nih.gov/7714088/ https://www.nejm.org/doi/full/10.1056/NEJMoa012908 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141719/ https://www.arcjournals.org/pdfs/ijrsb/v3-i11/7.pdf https://pubmed.ncbi.nlm.nih.gov/27569118/ https://pubmed.ncbi.nlm.nih.gov/23408502/ https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.2019.33.1_supplement.819.10 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017674/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526871/ https://pubmed.ncbi.nlm.nih.gov/23707514/ https://pubmed.ncbi.nlm.nih.gov/20921964/ https://pubmed.ncbi.nlm.nih.gov/29727683/ https://pubmed.ncbi.nlm.nih.gov/15522942/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607739/ https://pubmed.ncbi.nlm.nih.gov/33530881/ https://www.biorxiv.org/node/93305.full https://www.health.harvard.edu/heart-health/abundance-of-fructose-not-good-for-the-liver-heart https://pubmed.ncbi.nlm.nih.gov/25909219/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783752/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1413655/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783752/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470960/ https://europepmc.org/article/MED/22402737?javascript_support=no https://www.ncbi.nlm.nih.gov/pubmed/10232622 https://pubmed.ncbi.nlm.nih.gov/21410865/ This list compiled over years of research by the user known as Pottenger's Human on youtube. Feel free to copy and paste this anywhere you like, no accreditation needed!
  • @phil-spinelli
    stuff like this should be taught in school and pushed out to the public. it would help keep people healthy and drive down health insurance cost
  • @RinTexas
    Thanks. To reduce toxin exposure, I switched from carpet to hard wood floors. Previously, when I vacuumed, the vacuum cleaner just filled up way to quickly. Now keeping things clean is much easier.
  • @gronig6pat833
    My primary healthcare provider knows i practice Fasting ( 9 months now). She was initilially slightly horrified and bemused. At the outset of my last visit she asked outright " am i still doing it?" I replied in the affirmative that yes i am and feel great. I did not go into any detail whatsoever but mentioned Weightloss, inflammation and that i am a believer in autophagy. She has no idea what autophagy meant. Still pushing Statins but will not have my fasting insulin tested. Oh 🇨🇦 !!!
  • @F8Tributo
    This dovetails right into Dr Thomas Seyfried's research and 150 papers on the metabolic origins and usefulness in the treatment of cancer.
  • @TheDonwiggins
    Seasonal diet makes the most sense from an evolutionary perspective. The shock from switching also helps the microbiota.
  • Dr. Ben Bickman also pointed out that metformin damages mitochondria. I take the max dose. I am angry because my endocrinologist considers metformin harmless and wants me to continue using it. But here I am, a diabetic that eats almost no glucose, fighting cancer, that is working very hard to make my body as hostile to that cancer as possible.
  • @Morese56
    Oh talking to a primary care doc who prescribed a drug that they didn’t know in the first place would hurt our mitochondria is always a good idea. I n my experience in this life I do not trust very few WM doctors with any chronic illness or disease. Peace
  • Great video. Just a few comments, from my experience suffering from cronic fatigue due to Ross River fever. Viruses also damage mitochondria. I did take the supplements of CoQ10, l-carnitine, ala, etc, but they only helped so much. The best thing I did was intermittent fasting.Twice a month for four or five months, anywhere between 36 to 48 hours. I could see the results within 3 days of fasting each time. I don't need to fast anymore. I'm very healthy. I'm 57 and I don't take any prescription medication. If any of my symptoms come back, the only thing I will do is intermittent fasting. Of course I always eat healthy too.
  • It's worth mentioning that 1/3rd of the body weight is entirely mitochondria and by simply checking one's body temperature will let you know how efficient their working (closer to 98.6 the better). It's said that mitochondria make 15 degrees more heat than the ambient temp around them. Yes that's right, we get hot when we exercise because our mighty mitochondria are hard at work.
  • @palindrome06
    I hate that sunflower oil is in too many things.
  • @deepuls545
    Excellent program on such an important topic as Dr. Kuehne explains this so well. Pithy, succinct with great takeaways. For mitochondria, the type of exercise I have learned from my CPT and Advanced Senior Fitnesss Training was Zone 2 cardio. Resistance training is critical as well and for the myokines and helping with metabolic health. Would love for you to explore exercise and its effect on health markers. Thank you - will pass on.
  • @megabaneen8057
    Excellent info - PQQ is also good for mitochondrial health
  • Why recommend keto only short-term, or as needed (for example, cancer)? After 2 years in nonstop ketosis, I have NO desire to return to the foods that were making me sick.
  • Of course, you are aware that coq10 Ubiquinol is far more bio-available that regular COQ10 - Ubiquinone. Vitamin E- Tocopherols versus regular vitamin E and for vitamin K2 - MK7 is recommended as best. Anyone taking statins should be made aware that the statin also inhibits the liver's production of the COQ10 enzyme thus requiring supplementation.
  • Good evening! Thank you very much for sharing your knowledge. I llike your videos , they re short , informative, to the point, clear speech and no bubbling. Greetings from Greece
  • @jackportugge5647
    Interesting information. From my personal experience i agree with your take on autophagy, even because e can combine exercise and fasting in a way to trigger autophagy.
  • Hello,respected sir very nice suggestions for Gut health issues with Gallbladder chronic cystitis issues and huge bloating issues